Parent announcements are broad funding opportunity announcements allowing applicants to submit investigator-initiated applications for specific activity codes. They are open for up to 3 years and use standard due dates.

Not all NIH Institutes and Centers participate on all parent announcements. Before submitting your application, make sure the NIH Institute or Center that might be interested in your research is listed as a participating organization in the announcement.
Please note that R01 applications have three options:

PA-19-091- NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
PA-19-055- Research Project Grant (Parent R01 Clinical Trial Required)
PA-19-056- Research Project Grant (Parent R01 Clinical Trial Not Allowed)

this link will take you to all the (R) Research Announcements:

https://grants.nih.gov/grants/guide/parent_announcements.htm